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Beilstein J. Org. Chem. 2018, 14, 407–415, doi:10.3762/bjoc.14.29
Graphical Abstract
Figure 1: α-Amanitin.
Figure 2: Structure of the ligands cyclo[DKP-RGD] (1), NH2CH2-cyclo[DKP-RGD] (2), cyclo[DKP-isoDGR] (3), NH2CH...
Figure 3: Structure of the α-amanitin conjugates: cyclo[DKP-RGD]-uncleavable-α-amanitin (7), cyclo[DKP-isoDGR...
Scheme 1: Synthesis of α-amanitin-cyclo[DKP-RGD] and α-amanitin-cyclo[DKP-isoDGR] conjugates 7–10. Reagents a...
Scheme 2: Synthesis of cyclo[DKP-isoDGR]-PEG-4-Val-Ala-α-amanitin conjugate 11. Reagents and conditions: a) 4...